Oswald Schmiedeberg (1838 – 1921)

Oswald Schmiedeberg (1838 – 1921), a Baltic German pharmacologist, was born at Gut Laidsen in the Imperial Russian province of Courland. In 1866 he earned his medical doctorate from the University of Dorpat with a thesis concerning the measurement of chloroform in blood. In 1872 he became a Professor of Pharmacology at the University of Strasbourg, where he remained for the next 46 years. He is recognized as the "father of modern pharmacology". His work primarily dealt with finding the correlation between the chemical structure of substances and their effectiveness as narcotics.







Dr.J.Ezhil Ramya MD
Chair Professor


The Department of Pharmacology, established in 1967 under Dr.Mrs.C.K.Thampai, was headed by doyens like Dr.Vijayasekaran, Dr.Kanagambal & Dr.Vamsadhara. We are presently a postgraduate department with an well structured graduate program, systematic postgraduate training with special emphasis on clinical pharmacology. The Pharmaco-vigilance pursuit of this department has been well received across various clinical departments of the affiliate hospitals. The Department has a well nursed animal research unit and a Museum that depicts the History of Medicine.



Academic Program


The Department has a well organized Graduate Programme with academic postings during the 3rd, 4th and 5thsemesters. The Graduate Program includes basic training in Pharmacogenetics, Pharmacogenomics, Pharmacoepidemiology, Toxicology, Theoretical Pharmacology, Dosology, Pharmacognosy, Medicine development and safety testing, Drug legislation and safety, Clinical pharmacology, Neuropharmacology, Psychopharmacology, Behavioral Pharmacology and Environmental Pharmacology.


Graduate Program with two MD scholars taken in, every year under selection from the government of Tamilnadu and affiliated to the TN Dr MGR Medical University, Chennai. The academic training includes Pharmacogenetics, Pharmacogenomics, Pharmacoepidemiology, Toxicology, Theoretical Pharmacology, Dosology, Pharmacognosy, Medicine development and safety testing, Drug legislation and safety, Clinical pharmacology, Neuropharmacology, Psychopharmacology, Behavioral Pharmacology and Environmental Pharmacology.The Postgraduate Program also includes a series of predetermined symposia, seminar, Journal Clubs, Lecture Sessions, Case discussion, Pharmaco-Vigilance Audit and Medical Audit Meet. The residents also involve in training Pharmacology and Therapeutics to students of graduate medical students. The residents train in our department to Independently plan and undertake research related to drugs (basic as well as Clinical Pharmacology) and communicate the findings in conferences / journals, Set up therapeutic drug monitoring, ADR monitoring, therapeutic audit and drug information services, Plan and conduct toxicity studies and clinical trials, Educate the public about use and misuse of drugs, Supervise breeding and upkeep of small laboratory animals and mature as medical advisor in a hospital or pharmaceutical house.

The Course : Pharmacokinetics, Pharmacodynamics, Adverse Drug Reactions, Drug Interactions, Pediatric Pharmacology, Geriatric Pharmacology, Drugs in Pregnancy and Lactation. Dosage calculation in special situations, Factors modifying drug action, Pharmacogenetics, Drug delivery systems and Fixed dose combinations, Gene therapy, Sources of drugs. Principles of Toxicology, Principles of prescription writing.

Systemic Pharmacology, Chemotherapy and Therapeutics: Pharmacology of drugs acting on autonomic, peripheral and central nervous systems; cardiovascular, endocrine, respiratory, renal, gastrointestinal and hematopoietic systems and treatment of diseases affecting these systems; Pharmacology of anti-microbial and anti-parasitic drugs and treatment of infective diseases; cancer chemotherapy, immuno-pharmacology and ocular Pharmacology, Dermatological pharmacology vitamins, Heavy metals and antagonists, Miscellaneous.

Experimental Pharmacology, Bioassay:
Experimental methodologies involved in the discovery of drugs (in vivo, in vitro ex vivo), animal handling and care, methods of anesthetizing animals and methods of euthanasia, restraining and blood collection methods. Drug screening methods involved in the evaluation of anti-ulcer, antidepressant, anti-anginal, anti-hypertensive, anti-arrhythmic, anti-diabetic, anti-cataract, anti-platelet,ticancer, anti-inflammatory, anti-diarrheal, anti-epileptic, analgesic, anti-thyroid, antipyretic, anti-glaucoma, anti-hyperlipidemic, anti-asthmatic drugs and cough suppressants. Drug screening methods used in screening anti-fungal, ante-helmenthic, antibacterial and antiviral agents. Drug screening methods for heart failure, posterior pituitary, adrenal, steroid (gluco & mineralo), testicular, parathyroid, ovarian, thyroid hormones, Methods involved in testing teratogenecity, carcinogenicity and organ toxicities in animals. Bio-assay and dose response relationship.

Clinical Pharmacology and Biostatistics: Principles of therapeutics, Individualisation of drug therapy, Drug regulatory systems, Placebo, Drug development, Pharmacoeconomics, Pharmacoepidemiology, Therapeutic drug monitoring, Ethics of clinical trial, Ethical committee, Drug utilization studies, Essential drug concept and rational drug use and patient compliance.

Through the academic sessions 2009-2011 the Department was busy with seminars & sessions on

  • Research Methodology,
  • Drug Treatment in Migraine
  • Molecular Pharmadynamics in Cancer Chemotherapy
  • Nano-Pharmacy of Skin Diseases
  • Pharmacovigilance
  • Treatment of Malaria
  • Drugs in Tuberculosis
  • Management of Epilepsy
  • Treatment of Snake Bite

Research Program

The Department has a central animal house under its aegis with 130 laboratory animals with facilities for breeding, intervention studies and trials.
The research protocols under study in the department include.

  • A Comparative Study of the effects of amlodepine and S amlodepine in patients with mild hypertension
  • A study of the efficacy and safety of ivermectin, permethrin and GBHC in patients with scabies
  • Efficacy and safety of Deflazocort in patients with nephrotic syndrome
  • A Comparative study of supplementation of Zinc probiotics in children with acute diarrheal disease
  • Antibiotic sensitivity patterns in patients with Urinary tract infections at TVMCH
  • A study of the prescription patterns in the Dermatology Outpatient Department of TVMCH
  • A study of incidence and prevalence of Depression in patients on Antihypertensive Treatment
  • Antibiotic sensitivity patterns in neonates with septicemia at TVMCH
  • A study of incidence and prevalence of adverse drug reaction in patients on Antihypertensive Treatment
  • Pharmaco-vigilance in the Department of General Medicine at TVMCH
  • A study of the clinical effects of single dose gabapentin as postoperative analgesia
  • A study of the awareness of Pharmaco-vigilance among the medical faculty and professionals at TVMCH

Pharmaco Vigilance Program


  • The Department organized a C.M.E on PHARMACOVIGILANCE was conducted on 2.4.2011 with 4 speakers and was attended by 75 delegates.
  • The Pharmaco-Vigilance Committee was constituted this year and started functioning since 1st Aril 2011.

Clinical Services